| Unlockable: | How to Unlock: |
| 10 Online Ranked Wins (25 points) | Win 10 online ranked games. |
| 15 Blocks (20 points) | Record 15 blocks or more with any team. |
| 15 Steals (20 points) | Record 15 steals or more with any team. |
| 15 Threes (15 points) | Make 15 three pointers or more with any team. |
| 20 Online Ranked Wins (35 points) | Win 20 online ranked games. |
| 2K Beats Playlist (10 points) | Create a 2K Beats playlist. |
| 3 Online Ranked Streak (15 points) | Win 3 online ranked games in a row. |
| 3-For-All (20 points) | Make at least 10 3pt FG's while shooting at least 45% from 3pt range with any team. |
| 30 Assists (20 points) | Record 30 assists or more with any team. |
| 3pt Shootout (25 points) | Win the 3pt Shootout. |
| 5 Online Ranked Streak (20 points) | Win 5 online ranked games in a row. |
| 5 Online Ranked Wins (15 points) | Win 5 online ranked games. |
| All-Heart (15 points) | Start the 4th period losing by 10 or more points and win the game with any team. |
| All-Hustle (15 points) | Record at least 10 offensive rebounds, 5 blocks and 5 steals with any team. |
| Allen Iverson (25 points) | Record at least 30 points, 10 assists and 5 steals with Allen Iverson. |
| Carmelo Anthony (25 points) | Record at least 40 points and 8 rebounds with Carmelo Anthony. |
| Chris Bosh (25 points) | Record at least 30 points, 15 rebounds and 2 blocks with Chris Bosh. |
| Chris Paul (25 points) | Record at least 25 points, 10 assists and 5 steals with Chris Paul. |
| Create Player (10 points) | Use the Create Player feature. |
| Defensive FG% (15 points) | Hold the opposing team's FG% below 40% with any team. |
| Dwight Howard (25 points) | Record at least 20 points, 15 rebounds and 5 blocks with Dwight Howard. |
| Dwyane Wade (25 points) | Record at least 30 points, 9 rebounds and 9 assists with Dwyane Wade. |
| East vs West (15 points) | User controlled team must win this matchup on All-Star difficulty. |
| Gilbert Arenas (25 points) | Record at least 35 points, 5 steals and 5 threes with Gilbert Arenas. |
| Good Hands (20 points) | Record 20 assists with no more than 5 turnovers with any team. |
| Ice Water (15 points) | FT% over 85% with at least 15 FTA's with any team. |
| Inside Domination (20 points) | Score at least 60 points in the paint with any team. |
| Kevin Garnett (25 points) | Record at least 25 points, 15 rebounds and 7 assists with Kevin Garnett. |
| Kobe Bryant (25 points) | Record at least 40 points, 5 rebounds and 5 assists with Kobe Bryant. |
| Kobe Bryant Dunk-Off (35 points) | Defeat Kobe Bryant in a Dunk-Off. |
| Lakers vs Clippers (15 points) | User controlled team must win this matchup on All-Star difficulty. |
| LeBron James (25 points) | Record at least 35 points, 7 rebounds and 7 assists with LeBron James. |
| Lights Out (15 points) | FG% over 55% for the game [minimum 40 FGA's] with any team. |
| Lockdown (20 points) | Record at least 10 blocks and 10 steals with any team. |
| Online Draft League (10 points) | Participate in an online draft. |
| Online League Game (15 points) | Complete an online league game. |
| Online Ranked Game (15 points) | Win one online ranked game. |
| Online Ranked NBA Blacktop Game (15 points) | Win one online ranked NBA Blacktop game. |
| Online Tournament Game (15 points) | Complete an online tournament game. |
| Pistons vs Heat (15 points) | User controlled team must win this matchup on All-Star difficulty. |
| Rebound Margin +7 (20 points) | Win the rebound battle by a margin of +7 with any team. |
| Second Unit (15 points) | Score at least 40 bench points with any team. |
| Sprite Slam Dunk (35 points) | Win the Sprite Slam Dunk Contest using LeBron James. |
| Spurs vs Mavericks (15 points) | User controlled team must win this matchup on All-Star difficulty. |
| Steve Nash (25 points) | Record at least 20 points and 15 assists with Steve Nash. |
| Suns vs Lakers (15 points) | User controlled team must win this matchup on All-Star difficulty. |
| Suns vs Mavericks (15 points) | User controlled team must win this matchup on All-Star difficulty. |
| Track Meet (15 points) | Score at least 15 fastbreak points with any team. |
| Trivia (35 points) | Answer 30 trivia questions correctly. |
| Yao Ming (25 points) | Record at least 30 points, 15 rebounds and 5 blocks with Yao Ming. |