| Unlockable: | How to Unlock: |
| Agency Athlete (20 points) | Run & jump your way to a 4-star Agility rating. |
| Agency Brawler (20 points) | Punch, jab, kick, and throw your way to a 4-star Strength rating. |
| Agency Explosives Expert (20 points) | Bomb your way to a 4-star Explosives rating. |
| Agency Marksman (20 points) | Hit your target every time to achieve a 4-star Firearms rating. |
| Agency Wheelman (20 points) | Accelerate and slide your way to a 4-star Driving rating. |
| Airtime Assassin (10 points) | Shoot and kill 5 gang members in a single jump (while airborne). |
| Bare-Knuckle Brawler (15 points) | Kill 150 gang members with your bare hands (or thrown objects). |
| Base Jumper (10 points) | Jump from the top of the Agency Tower and land in the water below. |
| Body Juggler (20 points) | Use explosives to keep a body up in the air for 10 seconds. |
| Car Juggler (20 points) | Use explosives to keep a car up in the air for seven seconds. |
| Chain Banger (10 points) | Blow up 100 explosive objects in 60 seconds. |
| Double Trouble (10 points) | Double your fun - complete your first mission in Co-op mode. |
| Driving High (10 points) | Achieve a height of 115 feet or more in a vehicle. |
| Firing Squad (15 points) | Fire away - shoot and kill 500 gang members using firearms. |
| First Blood (10 points) | Eliminate the first of 21 gang bosses. |
| Free Runner (50 points) | Collect 500 Agility Orbs. |
| Front Flipper (20 points) | Execute two forward flips in a single jump in a moving vehicle. |
| Global Impact (15 points) | Kill 15 gang members using the Observatory Globe. |
| Hazardous Hangtime (10 points) | Execute a 6-second jump in a vehicle. |
| High Flyer (10 points) | Make your way to the top of the Agency Tower. |
| It's Good To Be Connected (30 points) | Unlock all Supply Points |
| Los Muertos Cleanser (20 points) | Murder Los Muertos - Kill all Los Muertos gang members. |
| Los Muertos Intel Master (10 points) | Locate all Los Muertos dossier targets. |
| Mad Bomber (15 points) | Show your explosive personality - kill 500 gang members using explosives. |
| Master Agent (40 points) | Earn 4-star ratings in all five skill areas and then max out your Skills Status meters. |
| Orb Hunter (50 points) | Collect 300 Hidden Orbs. |
| Over Our Heads (30 points) | Successfully complete all 12 Rooftop Races. |
| Rampage (20 points) | Wreak havoc in 60-second increments. |
| Repo Man (10 points) | Commandeer 100 gang-controlled vehicles. |
| Ring Leader (20 points) | Drive through all of the unique Stunt Markers. |
| Road Warrior (30 points) | Successfully complete all 14 Road Races. |
| Roadkill King (15 points) | Mow down and massacre 175 gang members while driving. |
| Shai-Gen Cleanser (50 points) | Assassinate Shai-Gen - Kill all Shai-Gen gang members. |
| Shai-Gen Intel Master (10 points) | Locate all Shai-Gen dossier targets. |
| Shot-putter (10 points) | Throw any object (other than a grenade) 205 feet or more. |
| Stunt Driver (20 points) | Successfully execute five car stunts - front & back flips, barrel rolls, a long jump. |
| Tag Teamer (40 points) | Partner up and complete every mission in Co-op mode. |
| Take Me To Your Supply Point (10 points) | Unlock your first Supply Point. |
| The Trifecta (50 points) | Wipe the city clean by taking out all members of all three gangs. |
| Timed Stunt Driver (20 points) | Execute six car stunts in 60 seconds. |
| Untouchable Agent (15 points) | Kill 200 gang members without dying yourself. |
| Volk Cleanser (40 points) | Eviscerate the Volk - Take out all Volk gang members. |
| Volk Intel Master (10 points) | Locate all Volk dossier targets. |